The Cologne Center for Genomics has been acquired leading-edge technologies to help research groups of the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at the University of Cologne (UoC) finding answers in biology and medicine. The following table gives you a short overview about available platforms and their major application areas in regard to genotyping.

Comparison of SNP genotyping platforms available at the CCG

Many genotyping methods can be performed by the CCG. These can be grouped according to their plex level.

A typical GWA study of thousands of samples could for example start with high plex arrays from Affymetrix. Such studies typically provide a number (typically many hundreds) of positive signals that need to be verified in other collectives. Therefore other methods with a low/medium plex level must be used - eg Pyrosequencing or TaqMan. Finally, as a rule, some important or difficult SNPs remain that are genotyped with single plex procedures - such as TaqMan or pyrosequencing.This strategy maximizes the amount of genetic information that can be achieved with the available study resources.

* Current human high end array as an example; other products are available.

Contact

Genotyping Team ccg-genotypinguni-koeln.de