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Dr. Dmitriy Drichel: Publications

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2020

Kanoungi, G., Nothnagel, M., Becker, T, Drichel D The exhaustive genomic scan approach, with an application to rare-variant association analysis. Eur J Hum Genet (2020).
https://doi.org/10.1038/s41431-020-0639-3

2019

Halle U, Hähn C, Krause S, Krause-Kyora B, Nothnagel M, Drichel D, Wahl J (2019) Die Unsichtbaren. Menschen mit Trisomie 21 in Archäologie und Anthropologie. Arch Inf, 42. Epub ahead of print.
Abstract

2018

Ben Krause-Kyora, Marcel Nutsua, Lisa Boehme, Federica Pierini, Dorthe Dangvard Pedersen, Sabin-Christin Kornell, Dmitriy Drichel, Marion Bonazzi, Lena Möbus, Peter Tarp, Julian Susat, Esther Bosse, Beatrix Willburger, Alexander H. Schmidt, Jürgen Sauter, Andre Franke, Michael Wittig, Amke Caliebe, Michael Nothnagel, Stefan Schreiber, Jesper L. Boldsen, Tobias L. Lenz & Almut Nebel.
Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans.
Nature Communications, 1569 (2018) doi:10.1038/s41467-018-03857-x
Abstract

2017

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Nat Commun, 8 Mar 2017; 8:14694. doi: 10.1038/ncomms14694
Abstract

Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, et al. “Identification and characterization of two functional variants in the human longevity gene FOXO3”. In: Nature communications 8.1 (2017), p. 2063.

Sukanya Horpaopan, Jutta Kirfel, Sophia Peters, Michael Kloth, Robert Hüneburg, Janine Altmüller, Dmitriy Drichel, Margarete Odenthal, Glen Kristiansen, Christian Strassburg, et al. “Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS)”. In: Hereditary cancer in clinical practice 15.1 (2017), p. 22.

AK Hoebel, D Drichel, M van de Vorst, AC Böhmer, S Sivalingam, N Ishorst, J Klamt, L Gölz, M Alblas, A Maaser, et al. “Candidate genes for nonsyndromic cleft palate detected by exome sequencing”. In: Journal of dental research 96.11 (2017), pp. 1314–1321.

2016

Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis. Spier I, Kerick M,Drichel D., Horpaopan S, Altmüller J, Laner A, Holzapfel S, Peters S, Adam R, Zhao B, Becker T, Lifton RP, Holinski-Feder E, Perner S, Thiele H, Nöthen MM, Hoffmann P, Timmermann B, Schweiger MR, Aretz S. Fam Cancer. 2016 Apr;15(2):281-8. doi: 10.1007/s10689-016-9870-z.
Abstract

Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample. Mobascher A, Diaz-Lacava A, Wagner M, Gallinat J, Wienker TF,Drichel D, Becker T, Steffens M, Dahmen N, Gründer G, Thürauf N, Kiefer F, Kornhuber J, Toliat MR, Thiele H, Nürnberg P, Steinlein O, Winterer G. PLoS One. 2016 Apr 7;11(4):e0152984. doi: 10.1371/journal.pone.0152984. eCollection 2016.
Abstract

Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. Spier I,Drichel D, Kerick M, Kirfel J, Horpaopan S, Laner A, Holzapfel S, Peters S, Adam R, Zhao B, Becker T, Lifton RP, Perner S, Hoffmann P, Kristiansen G, Timmermann B, Nöthen MM, Holinski-Feder E, Schweiger MR, Aretz S. J Med Genet. 2016 Mar;53(3):172-9. doi: 10.1136/jmedgenet-2015-103468. Epub 2015 Nov 27.
Abstract

2015

PLD3 in non-familial Alzheimer's disease. Heilmann S, Drichel D, Clarimon J, Fernández V, Lacour A, Wagner H, Thelen M, Hernández I, Fortea J, Alegret M, Blesa R, Mauleón A, Roca MR, Kornhuber J, Peters O, Heun R, Frölich L, Hüll M, Heneka MT, Rüther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, Tárraga L, Boada M, Maier W, Lleó A, Ruiz A, Nöthen MM, Ramirez A. Nature. 2015 Apr 2;520(7545):E3-5. doi: 10.1038/nature14039.

Novel genetic matching methods for handling population stratification in genome-wide association studies. Lacour A, Schüller V, Drichel D, Herold C, Jessen F, Leber M, Maier W, Noethen MM, Ramirez A, Vaitsiakhovich T, Becker T. BMC Bioinformatics. 2015 Mar 14;16:84. doi: 10.1186/s12859-015-0521-4.

2014

Rare variant testing of imputed data: an analysis pipeline typified. Drichel D, Herold C, Lacour A, Ramirez A, Jessen F, Maier W, Noethen MM, Leber M, Vaitsiakhovich T, Becker T. Hum Hered. 2014;78(3-4):164-78. doi: 10.1159/000368676. Epub 2014 Dec 10.

METAINTER: meta-analysis of multiple regression models in genome-wide association studies. Vaitsiakhovich T, Drichel D, Herold C, Lacour A, Becker T. Bioinformatics. 2015 Jan 15;31(2):151-7. doi: 10.1093/bioinformatics/btu629. Epub 2014 Sep 23.

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, Kornhuber J, Peters O, Naj AC, Chouraki V, Bellenguez C, Gerrish A; International Genomics of Alzheimer's Project (IGAP); Alzheimer's Disease Neuroimaging Initiative (ADNI), Heun R, Frölich L, Hüll M, Buscemi L, Herms S, Kölsch H, Scheltens P, Breteler MM, Rüther E, Wiltfang J, Goate A, Jessen F, Maier W, Heneka MT, Becker T, Nöthen MM. Hum Mol Genet. 2014 Dec 15;23(24):6644-58. doi: 10.1093/hmg/ddu372. Epub 2014 Jul 15.

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Thelen M, Razquin C, Hernández I, Gorostidi A, Sánchez-Valle R, Ortega-Cubero S, Wolfsgruber S, Drichel D, Fliessbach K, Duenkel T, Damian M, Heilmann S, Slotosch A, Lennarz M, Seijo-Martínez M, Rene R, Kornhuber J, Peters O, Luckhaus C, Jahn H, Hüll M, Rüther E, Wiltfang J, Lorenzo E, Gascon J, Lleó A, Lladó A, Campdelacreu J, Moreno F, Ahmadzadehfar H; Dementia Genetics Spanish Consortium (DEGESCO), Fortea J, Indakoetxea B, Heneka MT, Wetter A, Pastor MA, Riverol M, Becker T, Frölich L, Tárraga L, Boada M, Wagner M, Jessen F, Maier W, Clarimón J, López de Munain A, Ruiz A, Pastor P, Ramirez A. Neurobiol Aging. 2014 Nov;35(11):2657.e13-9. doi: 10.1016/j.neurobiolaging.2014.06.018. Epub 2014 Jun 20.

Analysis of the progression of systolic blood pressure using imputation of missing phenotype values. Vaitsiakhovich T, Drichel D, Angisch M, Becker T, Herold C, Lacour A. BMC Proc. 2014 Jun 17;8(Suppl 1):S83. doi: 10.1186/1753-6561-8-S1-S83. eCollection 2014.

The oestrogen receptor 2 (ESR2) gene in female-pattern hair loss: replication of association with rs10137185 in German patients. Redler S, Birch P, Drichel D, Hofmann P, Dobson K, Böhmer AC, Becker J, Giehl KA, Tazi-Ahnini R, Kruse R, Wolff H, Miesel A, Fischer T, Böhm M, Nuwayhid R, Garcia Bartels N, Lutz G, Becker T, Blume-Peytavi U, Nöthen MM, Messenger AG, Betz RC. Br J Dermatol. 2014 Apr;170(4):982-5. doi: 10.1111/bjd.12756.

Ramirez A, Heilmann S, Drichel D, Hernandez I, Lleó A, Lacour A, Rosende-Roca M, Mauleon A, Ruiz S, Alegret M, Espinosa A. Role of PLD3 rare variants in european

sporadic Alzheimer’s disease patients. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2014 Jul 1;10(4):P319-20.

2013

Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss. Nuwaihyd R, Redler S, Heilmann S, Drichel D, Wolf S, Birch P, Dobson K, Lutz G, Giehl KA, Kruse R, Tazi-Ahnini R, Hanneken S, Böhm M, Miesel A, Fischer T, Wolff H, Becker T, Garcia-Bartels N, Blume-Peytavi U, Nöthen MM, Messenger AG, Betz RC. Arch Dermatol Res. 2014 May;306(4):413-8. doi: 10.1007/s00403-013-1436-4. Epub 2013 Dec 19.

High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications. Röhr C, Kerick M, Fischer A, Kühn A, Kashofer K, Timmermann B, Daskalaki A, Meinel T, Drichel D, Börno ST, Nowka A, Krobitsch S, McHardy AC, Kratsch C, Becker T, Wunderlich A, Barmeyer C, Viertler C, Zatloukal K, Wierling C, Lehrach H, Schweiger MR. PLoS One. 2013 Jul 2;8(7):e67461. doi: 10.1371/journal.pone.0067461. Print 2013.

A one-degree-of-freedom test for supra-multiplicativity of SNP effects. Herold C, Ramirez A, Drichel D, Lacour A, Vaitsiakhovich T, Nöthen MM, Jessen F, Maier W, Becker T. PLoS One. 2013 Oct 30;8(10):e78038. doi: 10.1371/journal.pone.0078038. eCollection 2013.

Investigation of six novel susceptibility loci for male androgenetic alopecia in women with female pattern hair loss. Redler S, Dobson K, Drichel D, Heilmann S, Wolf S, Brockschmidt FF, Tazi-Ahnini R, Birch P, Teßmann P, Giehl KA, Kruse R, Lutz G, Garcia Bartels N, Hanneken S, Wolff H, Böhm M, Becker T, Blume-Peytavi U, Nöthen MM, Messenger AG, Betz RC. J Dermatol Sci. 2013 Nov;72(2):186-8. doi: 10.1016/j.jdermsci.2013.06.012. Epub 2013 Jul 16.

Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology. Heilmann S, Kiefer AK, Fricker N, Drichel D, Hillmer AM, Herold C, Tung JY, Eriksson N, Redler S, Betz RC, Li R, Kárason A, Nyholt DR, Song K, Vermeulen SH, Kanoni S, Dedoussis G, Martin NG, Kiemeney LA, Mooser V, Stefansson K, Richards JB, Becker T, Brockschmidt FF, Hinds DA, Nöthen MM. J Invest Dermatol. 2013 Jun;133(6):1489-96. doi: 10.1038/jid.2013.43. Epub 2013 Jan 28.

2012

Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss. Mahmoudi H, Redler S, Birch P, Drichel D, Dobson K, Tazi-Ahnini R, Teßmann P, Giehl KA, Kruse R, Lutz G, Hanneken S, Wolff H, Blume-Peytavi U, Becker T, Nöthen MM, Messenger AG, Böhm M, Betz RC. Arch Dermatol Res. 2013 Apr;305(3):249-53. doi: 10.1007/s00403-012-1296-3. Epub 2012 Nov 5.

Quick, "imputation-free" meta-analysis with proxy-SNPs. Meesters C, Leber M, Herold C, Angisch M, Mattheisen M, Drichel D, Lacour A, Becker T. BMC Bioinformatics. 2012 Sep 12;13:231. doi: 10.1186/1471-2105-13-231.

Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Redler S, Tazi-Ahnini R, Drichel D, Birch MP, Brockschmidt FF, Dobson K, Giehl KA, Refke M, Kluck N, Kruse R, Lutz G, Wolff H, Böhm M, Becker T, Nöthen MM, Betz RC, Messenger A. Exp Dermatol. 2012 May;21(5):390-3. doi: 10.1111/j.1600-0625.2012.01469.x.

Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss. Redler S, Brockschmidt FF, Tazi-Ahnini R, Drichel D, Birch MP, Dobson K, Giehl KA, Herms S, Refke M, Kluck N, Kruse R, Lutz G, Wolff H, Böhm M, Becker T, Nöthen MM, Messenger AG, Betz RC. Br J Dermatol. 2012 Jun;166(6):1314-8. doi: 10.1111/j.1365-2133.2012.10877.x.

Integrated genome-wide pathway association analysis with INTERSNP. Herold C, Mattheisen M, Lacour A, Vaitsiakhovich T, Angisch M, Drichel D, Becker T. Hum Hered. 2012;73(2):63-72. doi: 10.1159/000336196. Epub 2012 Mar 7.

2011

Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss. Redler S, Birch MP, Drichel D, Dobson K, Brockschmidt FF, Tazi-Ahnini R, Giehl KA, Kluck N, Kruse R, Lutz G, Wolff H, Becker T, Nöthen MM, Messenger AG, Betz RC. Br J Dermatol. 2011 Sep;165(3):703-5. doi: 10.1111/j.1365-2133.2011.10456.x. Epub 2011 Aug 4.

2010

Drichel D, Flohr M. Correlation functions in N= 3 superconformal theory. arXiv preprint arXiv:1006.3346. 2010 Jun 17.